Police were called shortly after 6pm on Friday, July 10 to reports of two men injured at Alexia Square, close to Crossharbour DLR station.
Officers attended and found a man, believed aged in his late teens or early 20s, suffering stab injuries. Emergency services provided first aid but despite their efforts, he was pronounced dead at the scene.
A second man, believed aged in his late teens, was taken to hospital by the London Ambulance Service. His condition is not known at this stage.
A crime scene remains in place. No arrests. Enquiries continues.
At this early stage anyone with information is asked to call police on 101 or tweet @MetCC and quote CAD6215/10July. Alternatively, contact the independent charity Crimestoppers on 0800 555 111.